Abstract: Pregnancy induced hypertension（PIH） is a characteristic disease of pregnant women with high morbidity, which does great harm to the pregnant, the fetus, and the newborns. It is one of the main causes of increasing mortality of the pregnant women and the puerperal babies. In nearly half a century, domestic and foreign scholars have done a lot of studies about its pathogenesis, such as producing excessive inflammatory response, endothelial injury, oxidative stress, maternal-fetal immune imbalance, trophoblastic ischemia, genetic susceptibility and other theories, but its pathogenesis has not yet been clarified. Recently many studies have found it has a higher genetic predisposition, associated with some gene polymorphisms and it is easier to develop to primary hypertension. Related gene mutation can cause abnormal gene expression, result in abnormalities of the number and function of gene products, so that induce PIH.

Key words: Hypertension, pregnancy-induced, Genes, Polymorphism, genetic, Pathogenesis