Abstract: Endometriosis is the common and frequent disease in the women of child-bearing age. Currently，the generally received pathogenesis of endometriosis is the theory of retrograde menstruation or implantation. Reflux of endometrium spill into the abdominal cavity，which must by adhere，invade and angiogenesis， developing endometriosis. In addition， this progress must be completed under the factors as some protease，cytokines and so on. Several proteins and cytokines，such as matrix metalloproteinase（MMP），tissue inhibitor of metalloproteinase（TIMP），Survivin（a member of the inhibitors of apoptosis protein）andvascular endothelial growth factor（VEGF），play an important role in the pathogenesis of endometriosis. By inhibiting or increasing the synthesis of these proteins or cytokines， we may get a new breakthrough in the cure of endometriosis.

Key words: ndometriosis, Matrix metalloproteinases, Tissue inhibitor of metalloproteinase-1, Genes, suppressor, Vascular endothelial growth factors