Abstract: Preeclampsia is considered leading cause of feto-maternal perinatal morbidity and mortality. It is very important to develop effective prediction and prevention of preeclampsia. Varied tests used to predict preeclampsia include clinical identification of high risk（medical history and examination），laboratory and hamodynamic tests. Among them，the promising tests are as following：risk factors include age；parity；history of preeclampsia in a previous pregnancy；family history of preeclampsia，multiple pregnancy and pre-existing medical conditions such as diabetes，chronic hypertention，renal disease；thrombophilia and autoimmune disease.The tests in early pregnancy for predicting of preeclampsia have better specificity than sensitivity，such as BMI＞34 kg/m2；MAP of 90 mmHg（1 mmHg=0.133 kPa）；uterine artery Doppler（bilateral notching） and angiogenic factors（PIGF，VEGF，sFlt-1），especially sFlt-1/PIGF. Although there are various treatment options for preventing preeclampsia， the beneficial effect were observed only in low aspirin and calcium.The need for continuing research to pathogenesis of preeclampsia that will find new biomarkers and design the promise predictive models. Better prediction will allow us to target existing prevention，such as it is，and to also develop new treatment in future.

Key words: Pre-eclampsia, Prediction, Prevention, Early pregnancy