Abstract: This summary aims to generalize the pathological process of the preeclampsia and its relationship with sFlt-1 and placental growth factor（PLGF）. PLGF is a member of the VEGF family，PLGF binds with Flt-1 receptor，and promotes
angiogenesis and trophoblast proliferation. These biological functions can be blocked by sFlt-1 receptor，sFlt-1 plays an important role in regulation PLGF. sFlt-1 concentrations are higher in preeclampsia serum and prior to the onset of the disease. Levels of PLGF are lower in preeclampsia serum compare to normal. This summarizes up the roles sFlt-1 and PLGF have played in the prediction of the diagnosis of preeclampsia as well as its seriousness， exploring the significance of the application of sFlt-1 and PLGF in the clinical diagnosis of preeclampsia.

Key words: Pre-eclampsia, Vascular endothelial growth factor receptor-1, Placental growth factor