Abstract: Objective：To investigate the influence of induction time on pregnancy outcomes in women with premature rupture of membranes (PROM) in full-term pregnancy. Methods: A total of 1 474 pregnant women with PROM were selected from Affiliated Hospital of Qingdao University and Linyi Central Hospital from January 2015 to December 2017. They were divided into four groups according to Bishop score and induction time including group A (Bishop score ≥6 points, and patients were induced by oxytocin without labor after 2 h of rupture), group B (Bishop score ≥6 points, and patients were induced by oxytocin without labor after 12 h of rupture), group C (Bishop score＜6 points, and patients were induced by oxytocin without labor after 2 h of rupture), group D (Bishop score＜6 points, and patients were induced by oxytocin without labor after 12 h of rupture). We analyzed the pregnancy outcomes in the four groups. Results: The rate of vaginal delivery had no significant difference between group A and group B (P＞0.05). The vaginal deliver rate in group D was higher than that in group C (P＜0.05). The rates of puerperal infection and complications of induction in group A were lower than those in group B (P＜0.05). The rate of complications of induction, fetal distress and neonatal admission in group C were higher than those in group D (P＜0.05). Conclusions: The induced labor can be conducted after 2 h of rupture when the cervical is mature in patients with PROM, otherwise it should be delay to after 12 h．

Key words: Fetal membranes, premature rupture, Labor, induced, Oxytocin, Pregnancy outcome