Abstract: MicroRNA (miRNA) is a small non-coding RNA expressed endogenously, which can regulate approximately 30% gene expression via posttranscriptional function. Many studies indicate that miRNA plays a critical role in regulating the proliferation, migration and invasiveness of trophoblast. Long non-coding RNA (lncRNA) is such a kind of non-coding RNA with length more than 200 nucleotides, which can regulate the proliferation, migration and invasiveness of trophoblast through epigenetic effect, the regulation of cellular cycle and cell differentiation. Moreover, the regular transduction of cellular signal pathway can keep the normal invasiveness of trophoblast to prevent it grows and invades without restriction like the tumor cells. Different RNA or signal pathway has different targets, which results in the change of invasiveness of trophoblast in different procedure. This paper aims at illuminating the effects and mechanisms of miRNAs, lncRNAs and related signal pathway on the invasiveness of trophoblast.

Key words: RNA, untranslated, MicroRNAs, Signal transduction, Long non-coding RNA, Trophoblast invasiveness