Abstract: Intrauterine device（IUD） is one of the widely used long-acting contraceptive methods. At present，our country has the widespread use of copper containing IUD，but the placement of IUD women often have some adverse reactions，such as menorrhagia，irregular bleeding，abnormal vaginal discharge，pain，especially with the highest incidence of abnormal uterine bleeding. Patients with a serious impact on recognition of copper containing IUD and acceptance，which has been plagued by a problem that can not be ignored in clinic. At present it has been proved that human endometrium contains a variety of angiogenesis factor. Vascular endothelial growth factor（VEGF） is an important regulator of endometrial vessels formed，and affected by many factors. A number of research on the relationship between VEGF and related factors and the copper IUD induced abnormal uterine bleeding，the copper containing IUD side reactions of targeted therapy has opened up a new prospect.

Key words: Intrauterine devices, Uterine hemorrhage, Vascular endothelial growth factors, Angiopoietins