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Mechanism Study of MAPK Pathway in PCOS and Monomeric Treatment of Traditional Chinese Medicine HU Die, REN Jia-jie, LIU Jia-ning, FENG Xiao-ling Journal of International Obstetrics and Gynecology    2024, 51 (6): 684-691.   DOI: 10.12280/gjfckx.20240713 Abstract （222）   HTML （23）    PDF （2385KB）（672）       Knowledge map    Polycystic ovary syndrome (PCOS) is a common and complex gynecological endocrine disorder that mainly affects women of childbearing age. Its main characteristics include ovulation disorders, insulin resistance and hyperandrogenemia. The mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in the occurrence of PCOS. It has been confirmed that the three classic MAPK pathways - extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK are closely related to the occurrence of PCOS. Once these pathways are abnormally activated, it will prompt the body to have a variety of adverse reactions and ultimately lead to PCOS. Specifically, it includes ovulation dysfunction, insulin resistance, elevated androgen levels, oxidative stress and inflammatory reactions. Studies have shown that a variety of traditional Chinese medicine monomers can regulate the activity and expression of MAPK signaling pathway-related proteins. These traditional Chinese medicine monomers include flavonoids, glycosides, terpenoids, alkaloids and polysaccharides. Through this modulation, they can effectively improve the pathophysiological process of PCOS patients, thus providing new ideas and methods for the treatment of PCOS. Table and Figures | Reference | Related Articles | Metrics

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Application of Three- and Four-Dimensional Transperineal Ultrasound in Diagnosis of Pelvic Organ Prolapse by Measuring Area of Levator Hiatus JIA Hong-jing, DENG Xue-dong, CHEN Xiao-min, CAO Jiao-jiao, MA Lei, LU Bing Journal of International Obstetrics and Gynecology    2021, 48 (4): 434-437.   DOI: 10.12280/gjfckx.20200825 Abstract （1979）   HTML （45）    PDF （12018KB）（6048）       Knowledge map    Objective: To investigate the value of three- and four-dimensional transperineal ultrasound in diagnosis of pelvic organ prolapse (POP) by measuring levator hiatus area (LHA). Methods: A total of 84 POP patients were collected as the POP group, and 69 cases of healthy women without POP during the same period were selected as the control group. All subjects in both groups were examined by three- and four-dimensional transperineal ultrasound. LHA in resting, maximum Valsalva-3D and maximum Valsalva-4D states were measured and compared, respectively. The difference of LHA in Valsalva-3D and Valsalva-4D was compared within the group. The ROC curves of the rest, Valsalva-3D and Valsalva-4D were drawn to determine the optimal cut-off value of LHA in diagnosis POP, then to evaluate its diagnostic efficacy and compare the differences between the three states. Results: The LHA in resting, Valsalva-3D and Valsalva-4D state in the POP group were larger than those of the control group, and the differences were statistically significant (all P<0.05). There was no significant difference between the LHA of Valsalva-3D and Valsalva-4D state in each group (all P>0.05). The cut-off value of the LHA to diagnose POP was 14.29 cm 2, 19.29 cm2, 19.90 cm2 in resting, Valsalva-3D and Valsalva-4D state, respectively. The areas under the curve (AUC) were 0.759, 0.959, 0.956, respectively. The difference between the AUC of Valsalva-3D and Valsalva-4D and the AUC of resting state was statistically significant (Z=4.980, P<0.01; Z=4.865, P<0.01), and there was no significant difference in AUC between Valsalva-3D and Valsalva-4D state (Z=0.157, P>0.05). Conclusions: The LHA measured by three- and four-dimensional transperineal pelvic floor ultrasound has high diagnostic value for POP, and there was no difference in diagnostic efficiency between the two. Table and Figures | Reference | Related Articles | Metrics

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Clinical Application of Stem Cell-Derived Exosomes in Gynecological Diseases GUO Shi-wei, SUN Jing-li, CHEN Zhen-yu, LIU Sen Journal of International Obstetrics and Gynecology    2024, 51 (3): 279-283.   DOI: 10.12280/gjfckx.20230955 Abstract （266）   HTML （9）    PDF （584KB）（508）       Knowledge map    Stem cell-derived exosomes (SC-Exo) are petite vesicles, released from stem cells. Exosomes originating from different cells or tissues play diverse roles in the pathogenesis and progression of diseases, and have made significant achievements and progress in various clinical fields. The application value of SC-Exo in gynecological diseases such as recurrent spontaneous abortion, polycystic ovary syndrome, premature ovarian insufficiency, intrauterine adhesions, wound repair in vaginal surgery, gynecological tumors and pelvic floor dysfunction is increasingly being recognized. SC-Exo can mediate the signaling and functional transfer of genetic information between targeted cells by releasing a variety of bioactive molecules such as nucleic acids, proteins, lipids and cytokines. It has potential benefits for the treatment of gynecological diseases and is a novel and promising therapeutic strategy. Reference | Related Articles | Metrics

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Application of 3D Printed Hydrogel Stents in Prevention and Treatment of Intrauterine Adhesion SHI Ming, SUN Ming-hui, YANG Wei-wei, HUANG Hui-hua, ZHANG Chang-lin, David YB Deng Journal of International Obstetrics and Gynecology    2024, 51 (3): 290-296.   DOI: 10.12280/gjfckx.20231104 Abstract （257）   HTML （17）    PDF （4256KB）（532）       Knowledge map    Intrauterine adhesion (IUA) often leads to amenorrhea, infertility, and recurrent miscarriage, seriously affecting the physical and mental health of women. Clinically, surgical separation is the main treatment for IUA, but this approach frequently results in postoperative recurrence and has poor treatment efficacy. 3D bioprinted scaffolds have emerged as a cutting-edge approach in the treatment of IUA, capable of separating damaged areas to prevent adhesion formation and undergoing controllable in vivo degradation without the need for surgical removal. These scaffolds can be used for drug loading, stem cell transplantation, and exosome delivery, enabling the release of drugs or growth factors to the injured area to promote tissue repair and regeneration. Transplanting 3D bioprinted hydrogels loaded with stem cells or stem cell-derived exosomes to the damaged area can effectively promote the repair of IUA and improve pregnancy rates. 3D bioprinting can provide personalized treatment plans for patients, and the combined treatment strategy with stem cells or stem cell-derived exosomes holds promise as a powerful tool for treating IUA. Table and Figures | Reference | Related Articles | Metrics

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The Relationship between Inflammatory Cytokines and Embryo Arrest LIU Bing-bing, XU Yan-ning, CHEN Ling Journal of International Obstetrics and Gynecology    2023, 50 (4): 409-415.   DOI: 10.12280/gjfckx.20230007 Abstract （823）   HTML （30）    PDF （763KB）（1660）       Knowledge map    Embryo arrest is a common early pathological pregnancy in which is caused by defects of fertilized eggs or adverse pregnancy factors of the mother, resulting in the embryo to stop developing during pregnancy. The incidence of embryo arrest has increased year by year, becoming the most common complication of pregnancy. It may eventually lead to spontaneous abortion and missed abortion. Many factors are related to the occurrence of embryo arrest and about half of them are related to immune factors. Cytokines are a class of biologically active molecules that modulate immune response, among which inflammatory cytokines are related to inflammation. Uterine decidua and trophoblast cells can secrete a variety of inflammatory cytokines. Recent studies have shown that in the process of embryonic development, different cytokines cooperate, depend on and antagonize each other to form a cytokine network and participate in the maternal fetal interface immune response. But the exact mechanism of inducing embryo arrest is still unclear. This review focused on the relationship between inflammatory cytokines and embryo arrest and the related mechanism, in order to laying a theoretical foundation for the prevention of embryonic abortion and the development of targeted therapeutic agents. Reference | Related Articles | Metrics

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Advances in Research on Hydroxychloroquine in the Improvement of Placenta-Mediated Pregnancy Complication LI Jia-po, CHEN Bing-nan, ZHANG Li-yang, LI Fan, FU Yue, QIAO Chong Journal of International Obstetrics and Gynecology    2021, 48 (3): 241-246.   DOI: 10.12280/gjfckx.20200867 Abstract （2410）   HTML （358）    PDF （758KB）（7748）       Knowledge map    Hydroxychloroquine (HCQ) is a widely used antimalarial drug that inhibits cellular autophagy. HCQ can be used in women with rheumatic diseases who planning pregnancy and is recommended for continued use during pregnancy. In recent years, the use of HCQ in pregnancy has received increasing attention due to its immunomodulatory and endothelial protection effects in autoimmune diseases. There is a clear benefit in pregnant patients with autoimmune diseases, such as systemic lupus erythematosus and antiphospholipid syndrome, but it remains unclear whether there is a general benefit for patients without autoimmune diseases. HCQ has anti-inflammatory, immune regulation, anticoagulant, antithrombotic, antioxidant and endothelial protection effects. The modulation of immunity in pregnancy can be multifaceted, multi-level. This paper discusses the mechanisms and advances in the use of HCQ in pregnancy and the improvement of placenta-derived pregnancy complications. Reference | Related Articles | Metrics

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Research Progress of Drugs for Maintenance Treatment for Platinum-Sensitive Recurrent Ovarian Cancer CHANG Xin, HAN Lu Journal of International Obstetrics and Gynecology    2022, 49 (4): 382-387.   DOI: 10.12280/gjfckx.20220004 Abstract （1453）   HTML （40）    PDF （711KB）（4169）       Knowledge map    As the worst prognosis malignant tumor in gynecological diseases, ovarian cancer is more insidious and difficult to be diagnosed in the early stage. The recurrence rate of ovarian cancer patients is extremely high after the standard treatment regimen of comprehensive staging surgical and chemotherapy with platinum or paclitaxel drugs. Patients with recurrence are prone to develop platinum resistance after multiple chemotherapy sessions, and the therapeutic effect is getting worse. Therefore, how to reduce tumor recurrence, prolong patients′ survival time and improve quality of life has always been a difficult point in clinical treatment of ovarian cancer. For patients with platinum-sensitive recurrent ovarian cancer, they need to be treated with maintenance therapy after surgery plus chemotherapy. Molecular targeted drug regimens such as anti-angiogenic drugs and poly (ADP-ribose) polymerase inhibitors are used to maintain the efficacy of post-chemotherapy treatment in order to prolong progression-free survival and delay recurrence, and improve survival and quality of life. The article reviews the current pharmacological approaches related to maintenance therapy for platinum-sensitive recurrent ovarian cancer and looks forward to the application of maintenance therapy in the treatment of platinum-sensitive recurrent ovarian cancer. Reference | Related Articles | Metrics

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Advances in the Neurobiology of Women with Chronic Pelvic Pain LIU Yan-min,JIANG Xiu-xiu Journal of International Obstetrics and Gynecology    2019, 46 (1): 32-36.   Abstract （885）      PDF （769KB）（7585）       Knowledge map    Pelvic pain is one of the common gynecological diseases in women, which mainly presents as chronic pelvic pain. It has not only a great impact on women′s posture and balance ability, but also severe influence on the quality of life and health. However, the biological basis and etiology of chronic pelvic pain are still unclear. Its evaluation and treatment are complicated, which brings great difficulties to the treatment and rehabilitation. We aim to review the innervation of internal and external reproductive systems, the imaging changes and pain susceptibility of central nervous, the interaction between cytokines and peripheral nerve fibers, the role of inflammation factor in reducing peripheral nerve sensitivity, the pain signals transmission and neurons kinase signaling pathways activation mediated by sodium channel to further provide a theoretical basis for the prevention and treatment of female pelvic pain. We focus on the role of signaling pathways and cytokines in the pathogenesis of pain. Related Articles | Metrics

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Research Progress in Vaginal Ecosystem XIAO Bing-bing;LIAO Qin-ping Journal of International Obstetrics and Gynecology    2011, 38 (6): 479-482.   Abstract （1776）      PDF （247KB）（5278）       Knowledge map    The vagina is a dynamic and finely tuned ecosystem in which homeostasis depends on mutually beneficial interactions between a human female and her resident microorganisms. In recent years，the development and introduction of cultivation-independent molecular-based techniques have provided new information about the composition of normal vaginal flora，“normal flora” is a concept currently being redefined.Dominance by lactic-acid producing microbes appears to be the cornerstone of microbial health. Numerous factors（both internal and external） have the potential to disrupt the vaginal ecosystem's fragile balance，and different racial groups，different geographical region have significant difference in what is the dominant vaginal organisms. Related Articles | Metrics

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Research Progress on the Relationship between Folate Metabolism Disorder and Recurrent Spontaneous Abortion YUAN Bi-bo, WANG Qiu-xia, LI Zeng-yan, MA Yan-hong Journal of International Obstetrics and Gynecology    2021, 48 (2): 191-195.   DOI: 10.12280/gjfckx.20200659 Abstract （1759）   HTML （58）    PDF （873KB）（8085）       Knowledge map    For the definition of recurrent spontaneous abortion, different countries and regions have not reached a unified standard in terms of the number of abortions and gestational weeks of abortion. Its etiology is complex, which has been a hot topic for research in recent years. With the deepening of research, many pathogenic factors have been identified, but the etiology of many patients is still unclear, which brings great difficulties to clinical diagnosis and treatment. As a carrier of one carbon unit, folic acid is an important material for nucleic acid synthesis and DNA repair. Its metabolism abnormality can lead to related diseases by interfering with DNA methylation and synthesis, affecting homocysteine level. The folate metabolic pathway is regulated by related enzyme activities, and there are genetic polymorphisms in key enzyme genes, which affect the process of folic acid metabolism by changing the enzyme activity. Recently, more and more studies have confirmed that abnormal folic acid metabolism can increase the risk of recurrent spontaneous abortion, and folic acid intervention can improve the pregnancy outcome and reduce the incidence of recurrent abortion, but the mechanism is still controversial. This article reviews the research progress on the correlation between folic acid metabolism disorder and recurrent spontaneous abortion, and to provide help for the diagnosis and treatment of recurrent spontaneous abortion. Table and Figures | Reference | Related Articles | Metrics

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The Effects of TNF-α and IL-6 on Skeletal Muscle of Fetuses with Fetal Growth Restriction WANG Yan, WANG Ya-hui, WANG Yan, PEI Fei Journal of International Obstetrics and Gynecology    2024, 51 (2): 161-166.   DOI: 10.12280/gjfckx.20231050 Abstract （264）   HTML （28）    PDF （710KB）（435）       Knowledge map    Fetal growth restriction (FGR) is a common obstetric condition and resulting in low birth weight and reduced muscle mass in newborns after birth. This may be closely related to the regulatory mechanisms of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Studies have found that these two inflammatory factors are expressed at abnormal levels in FGR fetuses, affecting the proliferation and differentiation of myoblasts, interfering with the normal development of skeletal muscle. Moreover, TNF-α and IL-6 can activate specific signaling pathways, such as nuclear factor-κB (NF-κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinase (MAPK), and other signaling pathways that regulate myocyte metabolism and function. Using specific anti-inflammatory drugs or biological agents to reduce the activity of TNF-α and IL-6 may help improve the skeletal muscle development in FGR fetuses. Overall, the role of TNF-α and IL-6 in the skeletal muscle development of FGR fetuses is a multifaceted and complex process, requiring further in-depth research to clarify their specific mechanisms, aiding to the understanding of the pathophysiology of FGR, and providing new ideas for the treatment of FGR fetuses. Reference | Related Articles | Metrics

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The Early Screen and Diagnosis of Ovarian Cancer HU Ling-yun;LI Ya-li Journal of International Obstetrics and Gynecology    2011, 38 (4): 302-305.   Abstract （1555）      PDF （248KB）（5144）       Knowledge map    Perimenopause is the age of high incidence of ovarian cancer， because there are no obvious symptoms in early stage and lack of effective early diagnostic tool，mortality is the highest in the gynecological cancers. Gene chips，proteomics and immunohistochemical tecnology and other research methods have become research hotspot in early diagnosis of ovarian cancer，but there is no definite conclusion. Therefore，we need to define a new systematic， highly sensitive and specific method in early diagnosis of ovarian cancer，and screening of early ovarian cancer in the population，so that can early diagnosis and treatment，then further improve the quality of life of patients. Related Articles | Metrics

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Translational Medicine in Improving Endometriosis Researches LANG Jing-he Journal of International Obstetrics and Gynecology    2011, 38 (4): 261-262.   Abstract （2565）      PDF （213KB）（5920）       Knowledge map    Endometriosis（EMs） typically affects women of reproductive age. The underlining mechanisms of EM are not fully disclosed and treatment regimens do not provide satisfactory effects. Eutopic endometrium， stem cells and archimetra have been highly recognized in explaining the development of endometriosis， which also have great contributions to disease diagnosis， therapy development and preventive measures both theoretically and practically. New concepts such as“source of diagnosing”and“source of healing”are introduced into diagnosis and management of EM， epidemiology researches are possible with the help of bioassays， these all suggest an important role of translational medicine in optimizing EM researches. Related Articles | Metrics

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The Research Progress on Related Risk Factors and Treatment of Sleep Disorders in Perimenopausal and Postmenopausal Women HE Fei, ZHOU Jian-hong, CHU Ke-tan Journal of International Obstetrics and Gynecology    2024, 51 (4): 412-416.   DOI: 10.12280/gjfckx.20240174 Abstract （307）   HTML （26）    PDF （868KB）（322）       Knowledge map    Sleep disorder refers to abnormal sleep quantity, quality or some clinical symptoms occur during sleep, which seriously affects human function and health. The incidence of sleep disorders is positively correlated with age, and perimenopause in women is usually the turning point of female sleep due to the high incidence of menopause syndrome and metabolic related diseases. Sleep disorders in perimenopausal and postmenopausal women are characterized by difficulties in falling asleep, sleep maintenance disorders, daytime dysfunction, and anxiety and depression in severe cases. According to the related risk factors, symptomatic treatment, alleviate menopause-related symptoms, improve sleep quality, increase effective sleep time, restore social function, and improve the quality of life are the goals of the treating of perimenopausal sleep disorders. Therapeutic measures for perimenopausal and postmenopausal sleep disorders include non-drug therapy (sleep hygiene education, cognitive-behavior therapy for insomnia) and pharmacological therapy (menopausel hormone therapy, psychotropic and sedative hypnotic drugs, melatonin, traditional Chinese medicine, etc.). This article reviews the research progress on the risk factors and diagnosis and treatment of sleep disorders in perimenopausal and postmenopausal women. Table and Figures | Reference | Related Articles | Metrics

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Progress on the Relationship between Apoptosis and Adverse Pregnancy Outcomes MA Ling, LI Ya-xi, ZHAO Min, WANG Jing, LI Hong-li Journal of International Obstetrics and Gynecology    2025, 52 (2): 121-126.   DOI: 10.12280/gjfckx.20241001 Abstract （354）   HTML （478）    PDF （6014KB）（119）       Knowledge map    Apoptosis is a programmed cell death that plays a crucial role in the physiological and pathological processes of pregnancy. Abnormal apoptosis, especially excessive apoptosis of trophoblast cells in the placenta, may lead to trophoblast dysfunction, abnormal vascular remodeling, increased oxidative stress, and immune imbalance, thereby cause adverse pregnancy outcomes such as recurrent spontaneous abortion (RSA), pre-eclampsia (PE), gestational diabetes mellitus (GDM), and preterm birth. The regulation of apoptosis is vital for pregnancy. In the RSA, p53-mediated apoptosis and abnormal expression of miR-184 and miR-27a disrupt the balance between trophoblast proliferation and apoptosis. In PE, the miR-4531/CX3CL1 signaling pathway is involved in the pathogenesis of PE by regulating vascular endothelial injury. In GDM, ghrelin shows potential therapeutic value by downregulating the endoplasmic reticulum stress signaling pathway. In preterm birth, endoplasmic reticulum stress induces apoptosis of alveolar epithelial cells via the inositol-requiring enzyme 1α(IRE1α)/c-Jun N-terminal protein kinase(JNK) pathway. Future research needs to further explore its mechanisms and therapeutic targets to provide new ideas for the prevention and treatment of adverse pregnancy outcomes. Reference | Related Articles | Metrics

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Research on Pathogenesis of Gestational Diabetes Mellitus and its Influence on Maternal and Infant JIE Jin-hua;XU Rong-xian Journal of International Obstetrics and Gynecology    2011, 38 (3): 197-200.   Abstract （2860）      PDF （203KB）（6256）       Knowledge map    Risk factors of gestational diabetes mellitus（GDM）include age，obesity，ethnicity，adverse obstetrical and neonatal outcomes，and family history of diabetes. Insulin resistance plays a main role in GDM. Impact of GDM on mothers and fetals is intimately related to levels of glycaemic control. Women with GDM are increased risk of pre-eclampsia，polyhydramnios，shoulder dystocia or cephalopelvic disproportion，injury of birth canal， caesarean delivery and diabetes after years，while their infants tend to experience higher rates of macrosomia， preterm birth，morbidity and mortality. The offspring of these women are also at increased risk of obesity and metabolism syndrome in childhood. Related Articles | Metrics

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The Cervical Cancer Microenvironment: an Immunologic Role in Disease CAO Jian-fang;HAO Min;ZHAO Wei-hong Journal of International Obstetrics and Gynecology    2015, 42 (3): 249-252.   Abstract （1279）      PDF （461KB）（5729）       Knowledge map    Cervical cancer is the second leading cause of cancer deaths for women globally worldwide. Persistent infection of high risk human papillomavirus（HR-HPV） is the main etiological factor for cervical cancer development. The changes of body immune system status especially microenvironment in situ is capable of mounting efficient immune responses against tumor antigens, so that most of the infected women can eliminate the virus and cervical precursor lesions displaying a central role in tumor progression. It is possible that vaginal microflora，vaginal mucosal defense system，immune cells and cytokines have been modulated in the cervical microenvironment. Any abnormality in the process will result in changing HPV natural history in the development of cervical intraepithelial neoplasias（CIN） and cervical cancer. The mechanism of cervical microenvironment immune dysfunction increased the risk of cervical cancer has not yet clearly known，and remains to be deeply investigated. Related Articles | Metrics

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The Etiology of Fetal Growth Restriction and Its Effects on the Long-Term Health of the Child WANG Ya-hui, WANG Yan, WANG Yan, PEI Fe Journal of International Obstetrics and Gynecology    2024, 51 (2): 152-156.   DOI: 10.12280/gjfckx.20230840 Abstract （306）   HTML （42）    PDF （658KB）（410）       Knowledge map    Fetal growth restriction (FGR) is one of the common and more complex complications of pregnancy, which refers to the inability of the fetus to reach its expected growth potential during pregnancy. The etiology of FGR is complex and varied, and may be caused by maternal, fetal or placental factors. Long-term follow-up studies of pediatric and adult patients with FGR have revealed adverse health outcomes. Fetuses with growth restriction lag significantly behind normal children in birth weight and length after delivery, and the vast majority of these children begin to experience significant growth catch-up early in life, but are at higher risk for metabolic problems. FGR is often associated with a range of long-term complications, such as neurologic deficits and abnormalities in skeletal muscle growth and metabolism, and is even associated with increased risk of metabolic syndrome and cardiovascular disease in adulthood. This has a serious impact on the physical health and quality of life of children with FGR. We summarize the pathogenic factors of FGR and its effects on the long-term health of children in order to provide theoretical support for the clinical prevention and treatment of FGR. Table and Figures | Reference | Related Articles | Metrics

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Role of STING Signaling Pathway in HPV-Related Malignant Tumors ZHANG Zhan, LIU Zhao-hui Journal of International Obstetrics and Gynecology    2023, 50 (1): 30-34.   DOI: 10.12280/gjfckx.20220376 Abstract （1276）   HTML （29）    PDF （696KB）（3968）       Knowledge map    Stimulator of interferon genes (STING) signaling pathway is a natural immune pathway, which can be activated by bacterial or viral DNA fragments in cytoplasm to promote type I interferon production through a series of downstream signaling pathways. It is a central part of the human anti-tumor immunity. Previous studies have found that STING expression was up-regulated in some human papilloma virus (HPV)-positive tumor tissues, and high expression of STING was associated with a better prognosis of tumor patients. We could observed remarkable regression of tumor when injecting STING agonists into tumor tissues. However, other studies believe that the immune escape of HPV could interfere with STING signaling pathways and other natural immune pathways at the transcriptional level, promote epigenetic silencing and autophagy degradation of STING, thus creating an immunosuppressive microenvironment of tumor and promoting tumor growth. Herein we will systematically elaborate the role of STING signaling pathway in HPV-positive malignant tumors and analyze the potential therapeutic value of STING agonists in HPV-positive tumors. Reference | Related Articles | Metrics

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Journal of International Obstetrics and Gynecology    2013, 40 (2): 105-107.   Abstract （1014）      PDF （244KB）（4587）       Knowledge map    Related Articles | Metrics