Research Progress of TUBB8 Mutation Related to Female Infertility

doi:10.12280/gjfckx.20210714

Abstract

Abstract:

Tubulin beta eight class Ⅷ (TUBB8) is one type of the β-tubulin only found in primates. The correlation between TUBB8 gene and female infertility was clarified in 2016. By summarizing the relevant reports, this paper summarize that more than 100 different mutations of the gene can affect the reproductive process to varying degrees and increase the possibility of female infertility. Many gene mutations can be classified and summarized according to their genetic pattern and base change. Based on the research at the gene level, it gradually reveals the error of the protein and the domain caused by the mutation of TUBB8. By explaining the abnormality at the molecular level to the cell level, it can summarize seven mechanisms causing female infertility, which happen in the whole process of pregnancy. At present, the research on TUBB8 has been gradually used in clinical works, such as the diagnosis and treatment of infertility and the improvement of assisted reproductive technology.

Key words: Tubulin, Oocytes, Genes, Mutation, Infertility,female

LI Tong-yue, WENG Jing. Research Progress of TUBB8 Mutation Related to Female Infertility[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 82-86.

Figures/Tables 2

References 30

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