Abstract: Deleted in liver cancer genes （DLCs） family is found in several human tissues, and expresses Rho GTPase activation proteins（RhoGAP）. Recent studies have suggested that DLCs were underexpressed or absent in various types of human cancers. DLCs negatively regulated Rho proteins, focal adhension proteins and their downstream effectors to restraint cellular cytoskeletal formation and focal adhesion reorganization and played important roles in tomorigenesis, cell proliferation, invasion and migration, DLCs proteins play roles in estrogen, progestin and insulin related tumors, since they can regulate the activities of DLCs proteins by post-translational modification.

Key words: Liver neoplasms, Gene deletion, Cell proliferation, Neoplasm invasiveness, Neoplasm metastasis