Abstract: Although hot flushes are the most common characteristic during menopause but underlying physiopathological mechanisms has not yet been clarified. Trials of drugs that selectively inhibit the re-uptake of serotonin and noradrenalin have shown some beneficial effects which provides new insight into the pathophysiology of hot flushes. A variety of chemical pathways have been proposed involving estrogen，serotonin，endorphin，noradrenalin and dopamine. Flushing occurs as a result of disturbance of the temperature regulating system situated in the hypothalamus on low estrogen conditions，and probably a reduction in the thermoneutral zone, within which fluctuations of basal body temperature do not provoke compensatory vascular responses. Many factors have been implicated, including hormone factors, serotonin, gonadotrophins and multip neurohumoral mechanisms.

Key words: TIDAL FEVER, Estrogens, Serotonin, Gonadotropin-releasing hormone, beta-Endorphin