Abstract: Annexin A4 (Anxa4) is an important member of the annexin protein superfamily which mediates cellular apoptosis, differentiation and regulates proliferation, invasion, metastasis, angiogenesis and chemoresistance of cancer. Recent studies showed that Anxa4 has changes in expression levels in many cancers such as different types of ovary and endometrial cancer: chemoresistant ovarian clear cell carcinoma compared with chemosensitive serous adenocarcinoma of the ovary and uterine serous carcinoma with aggressive biological behavior compared with uterine endometrioid carcinoma, Anxa4 is overexpressed. But in comparison with the sensitive parental cell line, Anxa4 is less expressed in the cisplatin-resistant ovarian serous adenocarcinoma cell line. Overexpression of Anxa4 induced resistance against apoptotic stimulation by chemotherapeutic drugs. Anxa4 accomplishes its biological functions associated with tumour chemosensitivity through a non-transcriptional mechanism via the regulation of calcium signals pathway and anti-cancer drugs transport, and also exerts its biological process through a transcriptional mechanism via NF-κB related genomic effect. In the article, we review about studies on the relationship between Anxa4 and gynecologic tumour to provide research data about molecular-targeted Anxa4 treatment.

Key words: Annexin A4, Transcription, genetic, Calcium signaling, Genital neoplasms, female